Multiple fire departments were called to a two-story home in the 300 block of Booker Road at 3:30 a.m., according to York County Emergency Management.
When crews arrived people were running from the farmhouse, WGAL News 8 reports citing a responding fire chief.
No injuries have been reported as of Monday afternoon.
Emergency crews remained on the scene for over three hours, dispatchers say.
The cause of the fire is unknown.
Delta-Cardiff Volunteer Fire Company continues to investigate.
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